Polynucleotides are injectable skin boosters made from purified DNA fragments (often salmon-derived) that stimulate the skin's own repair processes — boosting hydration, elasticity, and collagen. Unlike filler, they do not add volume; they improve skin quality from within.

They are popular for under-eye crepiness and dark circles, overall skin laxity, and dull or thinning skin. A course of 2 to 3 sessions spaced a few weeks apart is standard, with results building gradually and lasting several months.

Pricing is per session, and a series is recommended for meaningful improvement.

How much does a Polynucleotides cost?

Polynucleotide skin boosters nationally typically cost $500 to $900 per session, with most patients needing a course of 2 to 3 sessions.

Single session

Face or under-eyes

$500-900

Under-eye treatment

Per session

$500-800

Course of 3

Standard protocol

$1,400-2,500

Maintenance session

Every 6-9 months

$500-800

Last updated June 2026. Estimates reflect national averages and Get Clear Beauty provider data — read how we estimate prices.

What to ask your provider

Are polynucleotides the right choice for my skin concern?
How many sessions do you recommend?
How are they different from filler for my under-eyes?
When will I see results and how long do they last?
What product or brand do you use?
What is the per-session and full-course cost?

Frequently asked questions

How much do polynucleotides cost?

Polynucleotide treatments across the US typically cost $500 to $900 per session. A course of 2 to 3 sessions is standard, so factor the full series into your budget.

What are polynucleotides used for?

They are skin boosters that improve hydration, elasticity, and collagen. They are especially popular for crepey under-eye skin, dark circles, and overall skin quality. They do not add volume like filler does.

Are polynucleotides the same as filler?

No. Filler adds volume to fill hollows or lines. Polynucleotides improve the skin's quality and resilience from within without volumizing, which makes them useful for delicate areas like under the eyes.

How long do polynucleotide results last?

Results build over the course of treatment and typically last several months. Many patients maintain the effect with a session every 6 to 9 months.

Where can I find Polynucleotides near me?

Get Clear Beauty lists verified Polynucleotides providers with prices posted up front across major US cities. Search by ZIP code to find the closest providers to your location and compare prices before you book.

Polynucleotides Treatment Guide

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What is a Polynucleotides?

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Frequently asked questions

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